Miebo®
perfluorohexyloctane ophthalmic solution
Clinical Snapshot
Miebo is the first and only FDA-approved treatment targeting evaporative dry eye through tear film stabilization. Its mechanism is entirely distinct from anti-inflammatory therapies — it acts directly at the tear film surface.
Mechanism of Action
Perfluorohexyloctane (PFHO) forms a stable semi-fluorinated alkane layer over the tear film, reducing evaporative tear loss by inhibiting lipid layer disruption. Unlike anti-inflammatory agents, Miebo targets the evaporative component directly.
Common Clinical Applications
- Signs and symptoms of dry eye disease
- Evaporative dry eye with meibomian gland dysfunction
Typical Dosing Principles
One drop in each eye four times daily.
Dosing information is provided for educational purposes. Always consult current prescribing information for specific dosing protocols.
Important Precautions
- Patients should be counseled about transient blurred vision following instillation.
- Contact lenses should be removed prior to use; may be reinserted 15 minutes after dosing.
Clinical Pearls
- Mechanistically distinct from all other approved dry eye therapies — targets evaporation rather than inflammation.
- Particularly relevant for patients with meibomian gland dysfunction and significant evaporative component.
- The water-free, preservative-free formulation is well-tolerated.
- Can be used in combination with anti-inflammatory therapies for patients with mixed-mechanism DED.
Commonly Associated Disease States
Select any disease state to explore its full entry in the Disease State Library.
Dry Eye Disease
One of the most prevalent conditions in optometric practice; a leading cause of patient dissatisfaction and reduced quality of life, with significant implications for contact lens wear, surgical candidacy, and systemic disease management.
Meibomian Gland Dysfunction
The leading cause of evaporative dry eye disease; present in the majority of dry eye patients and a critical target in comprehensive ocular surface management.
This entry is an educational reference designed to support clinical reasoning and therapeutic awareness. It does not constitute medical advice, establish a standard of care, or replace individualized patient assessment. Clinicians should consult current prescribing information before initiating any therapy.